This video explores the growing role of China as a global hub for innovative biopharma clinical trials, particularly in early-stage development. It discusses why multinational pharmaceutical companies are increasingly conducting Phase 1 and Phase 2 trials in China, highlighting advantages such as faster patient enrollment, strong academic research centers, earlier access to Asian patient data, and accelerated pathways toward simultaneous global commercialization and regulatory approval.

L.E.K. Consulting is a registered trademark of L.E.K. Consulting LLC. All other products and brands mentioned in this document are properties of their respective owners. © 2026 L.E.K. Consulting LLC

This collection brings together a focused selection of L.E.K. Consulting’s perspectives on the forces reshaping life sciences and biopharma. Across research, development and commercialization, companies are operating in a more demanding environment defined by rising scientific complexity, tighter capital discipline, increasing competition and higher expectation from patients regulators and investors. The articles in this booklet examine those pressures from multiple angles and offer practical guidance for leaders seeking to make better strategic choices in a period of rapid change.

Our insights highlight several of the issues now most relevant to industry decision makers. They look at how companies can raise R&D productivity and sharpen portfolio choices, how they can capture the next wave of revenue growth from both existing and future assets, how they can translate strategy into commercial impact through more targeted go-to-market models. They also address the operational and strategic implications of emerging technologies, which has the potential to reshape how innovation is developed, launched and scaled. Across these topics, a consistent message emerges: competitive advantage will increasingly belong to organisations that combine scientific ambition with disciplined decision—making and operational focus.

At L.E.K., we help clients interpret change and convert it into decisive action. By distilling market signals, emerging opportunities and the pressure points that matter most, this collection offers leaders a clear view of what it takes to steer successfully through a period of structural shifts.

For further insights into our analysis, download the full booklet.

L.E.K. Consulting is a registered trademark of L.E.K. Consulting LLC. All other products and brands mentioned in this document are properties of their respective owners. © 2026 L.E.K. Consulting LLC

This video explores the rapid rise of Asian life sciences innovation hubs, highlighting how countries such as China, Singapore, Korea, and Japan are strengthening their biomedical ecosystems through investments in R&D, infrastructure, and talent. It examines the five foundational pillars of successful innovation hubs, using Singapore as a case study to discuss both ecosystem progress and remaining structural gaps in commercialization, capital, and entrepreneurial depth.

L.E.K. Consulting is a registered trademark of L.E.K. Consulting LLC. All other products and brands mentioned in this document are properties of their respective owners. © 2026 L.E.K. Consulting LLC

As healthcare systems become increasingly networked, providers are under growing pressure to improve outcomes, increase efficiency and deliver sustainable value at scale. Hear from L.E.K. Consulting and United Therapy Group CEO Ilmarin B. Schietzel as they explore how healthcare organisations can combine performance improvement, AI and data-driven decision-making to unlock value across complex care networks. The session examines how digital infrastructure, operational excellence and technology-enabled care models can support scalability, improve patient outcomes and drive more efficient healthcare delivery across provider networks.

Footage courtesy of Healthcare Business International 2026 (HBI 2026).

L.E.K. Consulting is a registered trademark of L.E.K. Consulting LLC. All other products and brands mentioned in this document are properties of their respective owners. © 2026 L.E.K. Consulting LLC

Healthcare systems across Europe and beyond are facing growing pressure from ageing populations, rising chronic disease and workforce shortages. Hear from Eilert Hinrichs and panel members as they explore how integrated care models, home-based services and technology-enabled patient pathways can help healthcare providers redesign care for an ageing society. The discussion examines the evolving role of hospitals, care homes and community care, alongside the growing importance of AI, data and value-based healthcare models in improving outcomes while reducing system costs.

Footage courtesy of Healthcare Business International 2026 (HBI 2026).

L.E.K. Consulting is a registered trademark of L.E.K. Consulting LLC. All other products and brands mentioned in this document are properties of their respective owners. © 2026 L.E.K. Consulting LLC

Pharma services businesses are facing growing pressure from consolidation, evolving client expectations and the rapid adoption of AI across the drug development value chain. Hear from L.E.K.’s Andre Valente, and panel members as they discuss how CROs, medical imaging specialists and pharma services providers are adapting their business models to maintain scalability and differentiation. The session explores the impact of AI on clinical development and operational delivery, alongside the commercial and strategic levers helping pharma services companies improve efficiency, strengthen competitive positioning and drive growth in an increasingly tech-driven market.

Footage courtesy of Healthcare Business International 2026 (HBI 2026).

L.E.K. Consulting is a registered trademark of L.E.K. Consulting LLC. All other products and brands mentioned in this document are properties of their respective owners. © 2026 L.E.K. Consulting LLC

In this video, Yoshi Makita discusses the evolving role of in-house insurance agencies within Japanese corporate groups, in light of pending regulation from Japan’s Financial Services Agency (FSA). In-house agencies have traditionally arranged insurance for parent companies, subsidiaries and employees, while earning commissions from insurers — a structure that can create potential conflicts of interest. The FSA is raising expectations around governance, transparency and customer-first placement practices, meaning that many in-house agencies will need to reassess their operating models. The discussion highlights the strategic choices facing corporates: invest to professionalize and scale their agencies, or divest to specialist intermediaries better positioned to meet the higher standards. Makita also explores the implications for private equity, strategic investors and international brokers, noting that regulatory change and market fragmentation may create meaningful buy-and-build opportunities. The video emphasizes that successful transactions will depend not only on scale and capabilities, but also on thoughtful post-deal integration, employee continuity and long-term talent development.

L.E.K. Consulting is a registered trademark of L.E.K. Consulting LLC. All other products and brands mentioned in this document are properties of their respective owners. © 2026 L.E.K. Consulting LLC

Nearly all retail growth over the past decade has come from online channels. There is no tailwind for brick-and-mortar sales. Retailers cannot compete on legacy or retail fundamentals alone. Retailers must clearly define their role in the consumer trip and consistently deliver against the capabilities that matter most. Winning retailers are those that differentiate through strategy and focused execution, while others are losing relevance and falling out of the consideration set.

Consumers are taking fewer trips to physical stores and narrowing the set of retailers they do consider. Ecommerce sales are growing roughly two to three times faster than total retail sales, fundamentally reshaping how consumers shop. As a result, shoppers are prioritizing a smaller group of trusted physical retail destinations that can meet their needs efficiently, rather than visiting multiple stores. A small set of retailers is capturing a disproportionate share of consumer visits, while others fall out of the consideration set. Across approximately 130 major U.S. retailers, the 10 highest-traffic retailers account for roughly three-quarters of total visits (around 23 billion annual visits).

This shift is being accelerated by the continued rise of online-first players, most notably Amazon, as well as the growing advantage of mega-scaled retailers like Walmart and Target, which are capturing an increasing share of retail spend across categories. As consumers default to online channels for convenience, price transparency and speed, other retailers are accounting for a smaller share of trips (see Figure 1).

Within this backdrop, retailer performance is diverging sharply. Even retailers selling similar products to similar customers are seeing materially different outcomes in traffic, engagement and growth. The differential performance between winners and losers within categories has never been broader. This divergence points to strategy and execution, not category exposure, as the primary driver of performance.

Consumers are narrowing their consideration set. With a narrowing set of consumer journeys ending in retail stores versus online, many are consolidating trips and prioritizing a smaller group of retailers that can meet their needs efficiently. Rather than visiting multiple stores, they are increasingly choosing fewer, more-trusted destinations.

As a result, a small set of retailers is capturing a growing share of visits, while others fall out of the consideration set, reinforcing a widening gap in performance (see Figure 2).

What differentiates winners is how well they serve the specific “mission” a customer is trying to complete. Most purchases have a specific context or circumstance, whether it’s solving an immediate need, getting access to expertise, researching a considered purchase or browsing for inspiration. Retailers that orient their stores to differentially meet the needs of these missions become the default destinations, while others fall out of consideration.

Those gaining share stand out in five critical ways: They align tightly with key consumer missions where they can uniquely win versus Amazon or other online retailers, embed services where they add value, reduce friction through effective omnichannel capabilities, maintain assortments that feel current and worth revisiting, and foster engaged, well-equipped store teams who actively support customers in the moment of decision. While the relative importance of these factors varies by category, together they explain why some retailers continue to capture disproportionate consumer attention while others fall even further behind (see Figure 3).

1. Winning retailers are top of mind for specific consumer missions

Consumers do not choose retailers randomly. They select the retailer with the experience that best fits the specific trip they are trying to complete. Winning retailers are not broadly strong across all missions. Instead, they are consistently top of mind for one or two missions that they have uniquely configured their stores to serve, and that position drives a disproportionate share of visits and purchases (see Figure 4).

For example, AutoZone has established itself as a go-to destination for urgent, problem-solving trips in automotive. Its strong in-stock position, knowledgeable staff and fast fulfillment enable it to capture time-sensitive demand.

Other retailers win by owning more discovery-driven missions. TJX and its HomeGoods banner have built strong positions around “treasure hunt” shopping, where frequently changing assortments and unexpected finds make browsing inherently engaging and fun for shoppers.

By contrast, retailers that do not clearly lead in any mission struggle to capture meaningful share. Stores such as Kohl’s and JCPenney compete across a broad set of categories but lack a clearly defined role in consumers’ minds, making them less likely to be considered.

Success in retail today is less about being everything to everyone and more about owning a distinct mission for your target consumer.

2. Services can reinforce a retailer’s relevance and drive consumers to the store

Services extend the role of the retailer beyond the product purchase. Depending on the category, offerings such as professional advice, installation, pet grooming, in-home support and consultations help meet a consumer’s need end-to-end while reinforcing the value of visiting a physical location (see Figure 5).

Services are not just an add-on. In many cases, they are a core driver of retailer choice, particularly when purchases require expertise or ongoing support. Retailers that embed services into the shopping experience are better positioned to capture high-intent trips and increase repeat visitation. Petco is a clear example, having built a differentiated position through grooming, veterinary care and training, driving incremental trips and deeper engagement.

This dynamic is also evident in home goods, where services are tied to inspiration and project-based needs. Retailers such as Williams-Sonoma have strengthened their premium cookware destination positioning through cooking classes, in-store demonstrations and expert guidance, while others offer design services and consultations to help customers plan and execute projects. These capabilities extend the role of the store beyond the transaction, providing both inspiration and support. Retailers without comparable service integration are less likely to be chosen for these missions, limiting their ability to capture high-intent demand.

3. Omnichannel capabilities reduce friction in the purchase journey

Many retailers now offer table-stakes omnichannel capabilities, but their impact depends on whether they make the consumer trip easier to complete. Consumers expect to move seamlessly between digital and physical channels, whether checking inventory before visiting, buying online and picking up in-store, or using expedited delivery (see Figure 6).

Winning retailers are also using digital and artificial intelligence (AI)-enabled tools within stores to elevate the experience, thereby equipping associates with better product information, enabling more personalized recommendations and helping customers quickly find and evaluate options. These omnichannel features can improve conversion, increase basket size and make in-store shopping more efficient. While many retailers offer elements of omnichannel, only a small subset have capabilities that consistently reduce friction across the journey (see Figure 7).

These capabilities are often critical to completing the trip efficiently. Home Depot illustrates this in project-based home improvement, where purchases require both planning and immediate execution. Investments in real-time inventory visibility, buy online/pick up in store and same-day fulfillment enable customers to quickly source the right products and support high-intent trips.

Retailers are also embedding digital and AI-enabled tools into their service models to reduce friction. Target, for example, has deployed a customer-facing AI agent to resolve postpurchase inquiries, improve response times and reduce reliance on in-store and call center staff. By automating routine interactions and surfacing information more efficiently, these tools free up associates to focus on higher-value needs. These capabilities complement traditional omnichannel services such as curbside pickup and same-day fulfillment, supporting both planned and immediate purchase occasions.

Omnichannel functionality is no longer a point of differentiation but a baseline expectation. Retailers that execute well will reduce friction and capture demand, while those that fall short risk losing relevance in the consideration set.

4. Assortment relevance drives repeat visits

Retailers must offer assortments that directly connect to the needs of the missions they are trying to capture. Depending on the need being served, consumers are more likely to return to retailers that consistently introduce new products, align with evolving preferences and deliver strong value alongside frequent restocking. Most often, consumers are seeking well-curated assortments instead of overly broad assortments when shopping in physical stores.

Assortment relevance is a key determinant of whether a retailer remains in the consideration set over time. Zara exemplifies this, leveraging a vertically integrated model to introduce new styles rapidly, stay aligned with emerging trends and offer fashion at accessible price points. This combination of newness and value reinforces its position as a destination for discovery and drives frequent visits (see Figure 8).

A similar effect is seen in off-price retail, where TJX sustains traffic through continuously changing assortments driven by opportunistic buying and high inventory turnover, enabling it to offer branded products at compelling value. The resulting “treasure hunt” experience encourages repeat visits, as consumers expect new finds each time they shop (see Figure 8).

By contrast, retailers that default to undifferentiated assortment lose repeat engagement and fall out of the purchase journey. Maintaining a dynamic, relevant assortment that delivers strong value against the specific needs of the consumer’s shopping mission is therefore critical not only for conversion, but also for sustaining long-term traffic and customer loyalty.

5. Highly engaged store associates support differential in-store experiences

For many categories, particularly more complex or considered purchases, store associates play a critical role in helping consumers complete the trip and have a positive experience. Knowledgeable staff guide product selection, answer questions and reduce uncertainty, making them the most important part of the in-store value proposition. Highly engaged employees bring differentiated retail strategies to life and enable highly positive consumer experiences.

This role is most pronounced where consumers lack expertise or purchases carry higher stakes, but it remains important across all retail environments. In higher-consideration categories, associates guide decisions and build consumer confidence. In more routine purchases, they improve efficiency, resolve issues quickly and contribute to a value-added in-store experience. Retailers that invest in training and empower associates to provide credible, hands-on support are better positioned to convert shoppers and build trust.
REI is a clear example, with store associates who are often category enthusiasts who can provide tailored advice on technical products, reinforcing the retailer’s position as a trusted resource (see Figure 9).

A similar dynamic exists in categories such as home improvement and electronics, where associate support can meaningfully influence purchase decisions. Retailers that combine product availability with knowledgeable in-store assistance are more likely to capture these trips, while those that lack this capability risk losing customers seeking guidance elsewhere.

As retail becomes increasingly mission-driven, strong in-store execution remains an important differentiator.

Conclusion

Across categories, a small set of retailers is pulling ahead by aligning their strategy to the specific missions they can win, while others continue to lose relevance.

Winning retailers have established a clear role in the consumer journey and consistently deliver against the capabilities that matter most: supporting key missions, embedding services, reducing friction through omnichannel, maintaining relevant and well-priced assortments, and providing in-store expertise.

Retailers that deliver across more of these five capabilities capture stronger traffic growth and exemplify a clear positive relationship between capabilities and performance (see Figure 10).

Where does your banner stand across these dimensions?

• Are you clearly associated with the missions that matter most to your customers, or are you competing broadly without a defined role?
• Are your services and omnichannel capabilities meaningfully adding value or reducing friction, or are you simply meeting baseline expectations?
• Does your assortment consistently feel relevant and deliver value, or does it give customers a reason to look elsewhere?
• Are your store teams enabling confident decision-making and a differentiated experience, or are they merely supporting transactions?

The gap between leaders and laggards is widening, and the cost of inaction is increasing. There are fewer and fewer basic retailers remaining in the market. Retailers need to make deliberate strategic choices across mission alignment, services, omnichannel, assortment and store execution in order to remain competitive.

For more information, please contact us.

L.E.K. Consulting is a registered trademark of L.E.K. Consulting LLC. All other products and brands mentioned in this document are properties of their respective owners. © 2026 L.E.K. Consulting LLC